ABSTRACT
Aim: The primary purpose of this study was to verify the effect of the refined vegetable oils on recurrence of coronary artery disease (CAD) and hypercholesterolemia (HC). Materials and methods: The retrospective cohort study was conducted on 140 sequential patients admitted and diagnosed with CAD and HC in a rural medical institute in Udaipur, Rajasthan, India. The complete medical case files were examined through the study investigators and relative findings were noted. The patient’s exposure to the refined vegetable oils were assessed via questioning; which was mainly divided into two groups as ‘exposed group’, those who were continued on the refined vegetable oils consumption and ‘non-exposed group’ , those who were stopped along with 6 month follow up for evaluation of recurrence of CAD and HC scheduled. CAD recurrence and HC recurrence were considered as the outcomes. The effect of the refined vegetable oils on recurrence of CAD and HC were investigated according to a logistic regression model.<br> Results: Total 107 patients fulfilled the inclusion criteria; 63 patients were in the ‘exposed group’. The 6-month follow up results were the refined vegetable oils consumption a 34.93 times the odds of hypercholesterolemia recurrence (P = 0.017; 95% CI for OR ranged from 1.90 to 643.46), while 26.60 times the odds of coronary artery diseases recurrence (P = 0.003; 95% CI for OR ranged from 3.04 to 232.62) in exposed and non-exposed group which were statistically significance difference found.<br> Conclusion: Refined vegetable oils tends to increase the risk of recurrence of coronary artery disease and hypercholesterolemia.
KEYWORDS:Cohort study, Coronary artery diseases, Hypercholesterolemia, Refined vegetable oil, Trans fat.